#1 sell your Plank, Marble, Crystal, Silk, Dust and Gem factories.
You get a massive bonus to Steel, Scroll, and elixir production, focus on those and trade them for the rest.
#2 Wayfarers taverns gotta go. They are twice as big as your residences and only give half as much pop.
#3 The roads along the edge should be moved in. A road has 2 sides, and both should be used.
#4 Roads should be upgraded to the best available.
#5 Old culture should be replaced: Ancient grounds, Temple of ages, Temple of holy fire, ect. all should be replaced with your current best option (pond of recreation)
Here's an example:
It's not perfect, but it gives your 16+ empty expansions and increases your production of goods significantly
the stuff on the left is what I think you should sell. I added a scrolls, 2 steels, and an elixir which will more than make up for the other factories.
Here's what it could look like with a portal