There aren't many tips to give as you have set the rules to in your own town only. If you allow crafting then the travelling merchants as suggested. Using spells wisely to boost efficiency but again you will be hampered by lack of supply. Just remember if you plan to do this to sentient goods stage that those relics go into goods as well so you will need to plan to stockpile those which will restrict your MA.
Thinking about it more it might be worth skipping the MA and maybe the barracks? Unsure you can spare the space. Probably best to work on min province expansion as well to keep costs down.
Before going to far down the path it might be worth looking at the cost for goods in some later chapters and the production values in the wiki. A quick maths calculation will tell you how long it might take based on the rules stipulated. You can then decide if the time is acceptable to you before you invest too much time.
Without going to wiki, here is how I'd approximate this on the back of the envelope:
If you need to build all manufactories, you will likely only be able to afford 1:1:1 setup in each tier, maaaybe 1:2:2 (with 2 for unboosted) - but this is likely pushing it. Assuming that all goods requirements are relatively even, you will be limited by the unboosted goods regardless if you run 1 or 2 unboosteds. So comparable "regular" city will run 3 or 5 boosteds in each tier, and trade these for the rest. So, with output of a single unboosted as 1 unit, 1 boosted outputs 8 units (once you hit 700% relic boost, and we ignore MH boost). So, regular city is going to have either 24 or 40 units of production split across 3 goods in a tier, so 8 or 13 units per good.
Our self contained city is stuck with producing 1 or 2 units per good, which makes it 8x or 6.5x slower. If you have the same build, and can trade you would do better ((8+1+1)/3 = 3.3 and (8+2+2)/3=4, or about 3 times slower) - but that won't be self-contained, would it?
Bottom line is, if you can go through a single chapter in 1.5 months on average, the self-sustained city will take a year - assuming that goods are your primary constraint. Which may or may not be true. You would do slightly better early on when regular city doesn't have a max boost, but it will all go downhill from there