In my main city, which is now in chapter 18, I have done every quest in every chapter, except for maybe less than 10 that were declinable at the time, such as ones asking to win fights at a time my city was not set up for fighting. Chapter 18 is my first chapter where I am not doing the quests as I get them, both because of lack of space and because of the way the new ascended goods are done. I am currently stopped on a quest that requires 3 of a guest race building that I have no use for at all to complete the chapter, and don't have the space or the goods just to build them. But since I have always done the quests because I want to know the amount of time it would take to complete it that way, I may still try and complete them all once I am a little further in the research. Plus, since this is the way the devs wrote the game, I want to follow it correctly in at least one city.